Meg Ryan doesn't think it is possible to have a successful career and a successful relationship.
The actress - whose marriage to Dennis Quaid failed when she had an affair with her "Proof of Life" co-star Russell Crowe in 2000 - has never understood how some women can balance both their personal and professional lives.
She said: "It's very difficult to be a career person and have a relationship. I didn't succeed at doing it at all. It's incredibly hard."
"I think you have to figure out some way of keeping all of those capabilities and requirements in your life in balance."
Meg - who is famous for starring in romantic comedies including "Sleepless in Seattle" and "When Harry Met Sally" - also revealed turning 40 six years ago has not had a major effect on her life.
Meg, who has a 15-year-old son Jack Henry with Dennis and an adopted three-year-old daughter Daisy True, added to Britain's Hello! magazine: "I just don't feel turning 40 is seminal or major in any way. I like my life right now, I really like it. Whatever it's taken to get here, I appreciate."