Patricia Arquette admits feeling a sense of "loss" when younger brother Alexis announced his plans to become a woman. The "Medium" star had questioned her open-mindedness when she doubted her brother's transgender plans.

The 39-year-old actress says, "I had all the questions [for him] at first: 'Do you love yourself? Is it something that you want to change about the way you look?' I get concerned when anybody I love wants to do any change to the way they look - where's this coming from and why?"

Sir Paul McCartney has introduced lover Rosanna Arquette to his young daughter.

The Beatles legend, who was spotted enjoying a romantic walk in London with Rosanna last week, invited the actress to his East Sussex mansion to meet four-year-old Beatrice.

Alexis Arquette thinks gay people need to speak up. Why? Because, you know, everything needs to happen on his time.

Alexis recently said that he's furious at Neil Patrick Harris and T.R. Knight for not talking about their sexuality at a gay fundraiser.